3.5 ‑Novel Advances in Vaccination in Organ
Transplant Recipients
Oriol Manuel, Lausanne, Switzerland

Vaccine-preventable infectious diseases remain a significant problem in immunocompromised patients such as solid-organ transplant (SOT) recipients. For example, the incidence of influenza infection and invasive pneumococcal disease is higher in SOT recipients than in the general population and it is associated with significant morbidity and mortality. The response to vaccination against these pathogens is variable depending on the type of organ transplant and the immunosuppressive regimen used, but overall a reduced immunogenicity after vaccination is expected in SOT recipients. Novel strategies to improve the efficacy of these vaccines are therefore needed. This includes intradermal vaccination, high-dose vaccination and the use of newer adjuvants such as cationic liposomes or toll-like receptors agonists. We will discuss the potential implementation of these strategies in the transplant population.